Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell Tissue Res. 2008 Jan;331(1):193-210. Epub 2007 Sep 9.

Wnt signaling and neural stem cells: caught in the Wnt web.

Author information

1
GSF-National Research Center for Environment and Health, Institute of Developmental Genetics, Ingolst├Ądter Landstrasse 1, 85764, Munich-Neuherberg, Germany.

Abstract

Wnt proteins have now been identified as major physiological regulators of multiple aspects of stem cell biology, from self-renewal and pluripotency to precursor cell competence and terminal differentiation. Neural stem cells are the cellular building blocks of the developing nervous system and provide the basis for continued neurogenesis in the adult mammalian central nervous system. Here, we outline the most recent advances in the field about the critical factors and regulatory networks involved in Wnt signaling and discuss recent findings on how this increasingly intricate pathway contributes to the shaping of the developing and adult nervous system on the level of the neural stem cell.

PMID:
17828608
DOI:
10.1007/s00441-007-0476-5
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center