Format

Send to

Choose Destination
J Neural Transm (Vienna). 2008;115(1):55-8. Epub 2007 Sep 10.

Myo-inositol-1-phosphate (MIP) synthase inhibition: in-vivo study in rats.

Author information

1
Department of Pharmacy Practice and Pharmaceutical Education, College of Pharmacy, University of Minnesota, Duluth, MN, USA. heinat@d.umn.edu

Abstract

Lithium and valproate are the prototypic mood stabilizers and have diverse structures and targets. Both drugs influence inositol metabolism. Lithium inhibits IMPase and valproate inhibits MIP synthase. This study shows that MIP synthase inhibition does not replicate or augment the effects of lithium in the inositol sensitive pilocarpine-induced seizures model. This lack of effects may stem from the low contribution of de-novo synthesis to cellular inositol supply or to the inhibition of the de-novo synthesis by lithium itself.

PMID:
17828434
DOI:
10.1007/s00702-007-0807-4
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center