Exploring the effects of C-reactive protein (CRP) and interleukin-1 beta single nucleotide polymorphisms on CRP concentration in patients with established coronary artery disease. Classification tree approach

Int Heart J. 2007 Jul;48(4):463-75. doi: 10.1536/ihj.48.463.

Abstract

Purpose: This study was designed to illustrate the effects of C-reactive protein (CRP) and interleukin polymorphisms on serum CRP levels.

Methods: A total of 390 patients with coronary heart disease (CHD) were recruited and high-sensitivity CRP levels were measured. Six polymorphic alleles on the genes of CRP, IL-1, and the IL-1 receptor antagonist were identified. A classification tree was applied to determine their effects and interactions on serum CRP levels.

Results: In the hypertensive CHD patients, the presence of CRP + 1059 GC heterozygotes was associated with a lower risk for elevated CRP levels (OR = 0.318, P = 0.001). The coexistence of CRP + 1059 GC and IL-1beta-511 (CT or TT) might result in reduction in the CRP levels compared to IL-1beta-511 CC (OR = 0.222, P = 0.088 and OR = 0.148, P = 0.060, respectively).

Conclusion: The results demonstrated the distribution of CRP-related polymorphisms and the interactions in Taiwanese patients with CHD.

MeSH terms

  • Aged
  • Alleles
  • Asian People / genetics
  • C-Reactive Protein / analysis*
  • C-Reactive Protein / genetics*
  • Coronary Disease / blood*
  • Coronary Disease / complications
  • Coronary Disease / genetics*
  • Female
  • Heterozygote
  • Humans
  • Hypertension / complications
  • Interleukin-1beta / genetics
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Receptors, Interleukin-1 / antagonists & inhibitors
  • Receptors, Interleukin-1 / genetics
  • Taiwan

Substances

  • Interleukin-1beta
  • Receptors, Interleukin-1
  • C-Reactive Protein