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J Clin Oncol. 2007 Sep 10;25(26):4033-42.

Antiangiogenics: the potential role of integrating this novel treatment modality with chemoradiation for solid cancers.

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1
Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA. duda@steele.mgh.harvard.edu

Abstract

Although still in very early stages of clinical development, the combination of antiangiogenics with contemporary chemoradiotherapy regimens has emerged as a feasible and promising approach to many cancers. We review the rationale and the current understanding of antiangiogenics and their therapeutic potential in combination with chemoradiotherapy. Finally, we offer a perspective on future research directions aimed at making this complex therapeutic approach successful in the clinic.

PMID:
17827451
PMCID:
PMC2686120
DOI:
10.1200/JCO.2007.11.3985
[Indexed for MEDLINE]
Free PMC Article
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