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J Am Soc Mass Spectrom. 2007 Nov;18(11):1921-4. Epub 2007 Aug 16.

Imaging of a beta-peptide distribution in whole-body mice sections by MALDI mass spectrometry.

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Novartis Institutes for BioMedical Research, Basel, Switzerland.


Mass spectrometric imaging was applied to assess compound distributions on whole-body sections of mice after i.v. dosing of a beta-peptide and an alpha-peptide control. Animals were sacrificed at different time points (5 min, 1 h, 24 h) post-dose, providing simultaneous spatial as well as kinetic information. As a result of this study, no detection of the alpha-peptide control was observed at 1 h post-dose, while retention of the beta-peptide was observed for longer than 24 h post-dose.

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