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Bioorg Med Chem Lett. 2007 Nov 1;17(21):5783-9. Epub 2007 Aug 28.

N4-phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease.

Author information

1
NIH Chemical Genomics Center, National Human Genome Research Institute, NIH, 9800 Medical Center Drive, MSC 3370, Bethesda, MD 20892-3370, USA.

Abstract

A series of 1,3,5-triazine-2,4,6-triamines were prepared and analyzed as inhibitors of glucocerebrosidase. Synthesis, structure activity relationships and the selectivity of chosen analogues against related sugar hydrolases enzymes are described.

PMID:
17827006
PMCID:
PMC2083578
DOI:
10.1016/j.bmcl.2007.08.050
[Indexed for MEDLINE]
Free PMC Article

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