Abstract
The presence of a 6,7-fused indole group in the indolomorphinans was considered to be responsible for the delta opioid selectivity for this class of ligands. Herein is shown that 5'-halogenated analogs of oxymorphindole are opioids with little selectivity for delta receptors over mu opioid receptors.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Halogens / chemistry*
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Morpholines / chemistry*
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Morpholines / pharmacology
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Receptors, Opioid, delta / drug effects
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Receptors, Opioid, mu / drug effects
Substances
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Halogens
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Morpholines
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Receptors, Opioid, delta
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Receptors, Opioid, mu
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oxymorphindole