N-{[(6-substituted-1,3-benzothiazole-2-yl)amino]carbonothioyl}-2/4-substituted benzamides: synthesis and pharmacological evaluation

Eur J Med Chem. 2008 May;43(5):1114-22. doi: 10.1016/j.ejmech.2007.07.008. Epub 2007 Jul 29.

Abstract

A series of 1,3-benzothiazol-2-yl benzamides (11-30) were prepared in satisfactory yield and evaluated for their anticonvulsant, neurotoxicity, CNS depressant study and other toxicity studies. All the synthesized compounds were in good agreement with elemental and spectral data. Majority of the compounds were active in MES and scPTZ screen and showed the decrease in the immobility time. None of the compounds had shown neurotoxicity or liver toxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anticonvulsants / chemical synthesis*
  • Anticonvulsants / pharmacology
  • Anticonvulsants / toxicity
  • Benzamides / chemical synthesis*
  • Benzamides / pharmacology
  • Benzamides / toxicity
  • Benzothiazoles / chemical synthesis*
  • Benzothiazoles / pharmacology
  • Benzothiazoles / toxicity
  • Central Nervous System Depressants / chemical synthesis*
  • Central Nervous System Depressants / pharmacology
  • Central Nervous System Depressants / toxicity
  • Chemical and Drug Induced Liver Injury / etiology
  • Chemical and Drug Induced Liver Injury / pathology
  • Chemical and Drug Induced Liver Injury / physiopathology
  • Liver Function Tests
  • Male
  • Mice
  • Rats
  • Rats, Wistar
  • Seizures / drug therapy
  • Seizures / etiology
  • Structure-Activity Relationship
  • Sulfides / chemical synthesis*
  • Sulfides / pharmacology
  • Sulfides / toxicity

Substances

  • Anticonvulsants
  • Benzamides
  • Benzothiazoles
  • Central Nervous System Depressants
  • Sulfides