Format

Send to

Choose Destination
Biochem Biophys Res Commun. 2007 Nov 9;363(1):71-6. Epub 2007 Aug 31.

Comparative analysis of mutants in the mycothiol biosynthesis pathway in Mycobacterium smegmatis.

Author information

1
Department of Biology, California State University-Fresno, Fresno, CA 937401, USA.

Abstract

The role of mycothiol in mycobacteria was examined by comparative analysis of mutants disrupted in the four known genes encoding the protein machinery needed for mycothiol biosynthesis. These mutants were sensitive to acid stress, antibiotic stress, alkylating stress, and oxidative stress indicating that mycothiol and mycothiol-dependent enzymes protect the mycobacterial cell against attack from various different types of stresses and toxic agents.

PMID:
17826740
DOI:
10.1016/j.bbrc.2007.08.142
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center