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Drug Discov Today. 2007 Sep;12(17-18):709-16. Epub 2007 Aug 28.

Human protein-protein interaction networks and the value for drug discovery.

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Cellzome AG, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.


Systematic genome-wide and pathway-specific protein-protein interaction screens have generated a putative, organizing framework of the spatial interconnectivity of a large number of human proteins, including numerous therapeutically relevant disease-associated proteins. The intrinsic value for drug discovery is that these physical protein-protein interaction networks may contribute to a mechanistic understanding of the pathophysiology of disease and can aid in the identification and prioritization of tractable targets and generate hypotheses on how to best drug non-tractable, disease-associated targets. Here, we review the 'therapeutic potential' of the 1st generation sub-genome-scale human interaction networks and disease-associated protein networks generated by yeast two-hybrid screens and affinity purification-mass spectrometry approaches.

[Indexed for MEDLINE]

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