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Can J Neurol Sci. 1991 Nov;18(4):492-8.

3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin.

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Center for Research on Occupational and Environmental Toxicology, Portland, Oregon 97201.


3-Nitropropionic acid (3-NPA)--a suicide inhibitor of succinate dehydrogenase--is a widely distributed plant and fungal neurotoxin known to induce a damage to basal ganglia, hippocampus, spinal tracts and peripheral nerves in animals. Recent reports from Northern China indicate that 3-NPA is also likely to be responsible for the development of putaminal necrosis with delayed dystonia in children after ingestion of mildewed sugar cane. This article discusses the role of 3-NPA in the causation of the disease in China, its neurotoxic effects in animals and the potential role for this compound as a probe of selective neuronal vulnerability.

[Indexed for MEDLINE]

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