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Am J Surg. 2007 Oct;194(4):426-32.

Scientific Impact Recognition Award. Sentinel node staging for breast cancer: intraoperative molecular pathology overcomes conventional histologic sampling errors.

Author information

  • 1Breast Health Services, Morton Plant Mease Health Care, 303 Pinellas St, Ste. 310, Clearwater, FL 33756, USA.

Abstract

BACKGROUND:

When sentinel node dissection reveals breast cancer metastasis, completion axillary lymph node dissection is ideally performed during the same operation. Intraoperative histologic techniques have low and variable sensitivity. A new intraoperative molecular assay (GeneSearch BLN Assay; Veridex, LLC, Warren, NJ) was evaluated to determine its efficiency in identifying significant sentinel lymph node metastases (>.2 mm).

METHODS:

Positive or negative BLN Assay results generated from fresh 2-mm node slabs were compared with results from conventional histologic evaluation of adjacent fixed tissue slabs.

RESULTS:

In a prospective study of 416 patients at 11 clinical sites, the assay detected 98% of metastases >2 mm and 88% of metastasis greater >.2 mm, results superior to frozen section. Micrometastases were less frequently detected (57%) and assay positive results in nodes found negative by histology were rare (4%).

CONCLUSIONS:

The BLN Assay is properly calibrated for use as a stand alone intraoperative molecular test.

PMID:
17826050
DOI:
10.1016/j.amjsurg.2007.07.008
[PubMed - indexed for MEDLINE]
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