Format

Send to

Choose Destination
Trends Genet. 2007 Oct;23(10):494-502. Epub 2007 Sep 7.

Polycomb Group proteins: an evolutionary perspective.

Author information

1
Lab of Chromatin Biology, The Rockefeller University, 1230 York Ave, Box 78, New York, NY 10065, USA.

Abstract

The chromatin-associated Polycomb Group (PcG) proteins were first identified in genetic screens for homeotic transformations in Drosophila melanogaster. In addition to body patterning in metazoans, members of the PcG are now known to regulate epigenetic cellular memory, pluripotency and stem cell self-renewal. Here, we discuss the functional versatility of the PcG family and the evolutionary history of a subset of these proteins including Drosophila E(z), Pc, Psc, dRing and their homologs in plants and animals. We propose that PcG gene expansion and diversification contributed significantly to the complexity of heritable gene repression mechanisms in extant multicellular organisms.

PMID:
17825942
DOI:
10.1016/j.tig.2007.08.006
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center