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Immunol Lett. 2007 Oct 31;113(1):1-5. Epub 2007 Aug 22.

Mimotope vaccines: epitope mimics induce anti-cancer antibodies.

Author information

1
Department of Dermatology, Medical University Vienna, Austria.

Abstract

Mimotopes are epitope-mimicking structures. When applied for immunizations they induce desired antibody specificities exclusively based on the principle of molecular mimicry. This is important as antibodies directed against tumor-associated antigens may harbor diverse biological effects depending on their epitope specificity. Thus they may inhibit or promote tumor growth. This review gives an update on different vaccination strategies based on the mimotope concept.

PMID:
17825923
PMCID:
PMC2999752
DOI:
10.1016/j.imlet.2007.07.008
[Indexed for MEDLINE]
Free PMC Article

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