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Trends Cell Biol. 2007 Sep;17(9):456-64. Epub 2007 Sep 6.

Mitochondrial protein-import machinery: correlating structure with function.

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1
Department of Biochemistry, La Trobe University, Melbourne 3086, Australia.

Abstract

Most mitochondrial proteins are synthesized in the cytosol, translocated into the organelle and directed along specific sorting pathways. Over the past 20 years, >30 proteins have been identified as having key roles in mitochondrial protein import. Recently, the elucidation of the structures of several import components has provided fresh insight into the import process. Here, we review the different pathways involved in sorting proteins into mitochondrial subcompartments. Along the way, we highlight the available structural information about the protein-import machinery and discuss how these structures correlate with previously ascribed functions. Future challenges for the cell biologists will be to use this structural information to test specific hypotheses addressing the molecular mechanisms of mitochondrial protein import.

PMID:
17825565
DOI:
10.1016/j.tcb.2007.07.010
[Indexed for MEDLINE]
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