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Eur Cytokine Netw. 2007 Sep;18(3):136-41. Epub 2007 Sep 7.

Polymorphisms in the IFNAR1 gene in patients with chronic hepatitis C: outcome of combined IFN-alpha therapy.

Author information

1
Department of Parasitology, Institute for Tropical Medicine, Wilhelmstr. 27, 72074 Tübingen, Germany.

Abstract

AIMS:

Interferon-alpha (IFN-alpha) alone or in combination with ribavirin has been used for the last decade in the treatment of chronic hepatitis C, although the achievement of a sustained virological response (SVR) has not been very satisfactory. The treatment outcome depends on viral genotypes and host genetic polymorphisms in genes involved in the IFN-alpha signaling cascade. In this paper, we investigated the distribution of two variants of the IFNAR1 gene, G17470C and L168V, in two patient groups having received IFN-alpha alone or in combination with ribavirin.

METHODS:

The analysis was performed using DNA sequencing of the relevant gene fragments.

RESULTS AND CONCLUSIONS:

This study suggests that when combination therapy with high dose IFN-alpha and ribavirin is administered, HCV genotypes and age rather than the IFNAR1 polymorphisms are the predictors of a sustained response.

PMID:
17823081
DOI:
10.1684/ecn.2007.0098
[Indexed for MEDLINE]
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