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Ophthalmology. 2007 Sep;114(9):1613-21.

Multifocal blue-on-yellow visual evoked potentials in early glaucoma.

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1
Department of Ophthalmology, Save Sight Institute, University of Sydney, Sydney, Australia.

Abstract

OBJECTIVE:

To determine the sensitivity and specificity of blue-on-yellow multifocal visual evoked potentials (mfVEPs) in early glaucoma.

DESIGN:

Cross-sectional study.

PARTICIPANTS:

Fifty patients with a confirmed diagnosis of early glaucoma and 60 normal participants.

METHODS:

Black-and-white mfVEPs and blue-on-yellow mfVEPs were recorded using the Accumap version 2.0 (ObjectiVision Pty. Ltd., Sydney, Australia). All patients also underwent achromatic standard automated perimetry (SAP).

MAIN OUTCOME MEASURES:

Multifocal VEP amplitude and latency values in glaucoma patients were analyzed and compared with those of the normal controls.

RESULTS:

Based on the definition of visual field defect, in the group of glaucomatous eyes with SAP defects, amplitude of blue-on-yellow mfVEP was abnormal in all 64 cases (100% sensitivity), whereas black-and-white mfVEP missed 5 cases (92.2% sensitivity). Generally, larger scotomata were noted on blue-on-yellow mfVEP compared with black-and-white mfVEP for the same eyes. There was high topographic correspondence between SAP and amplitude of blue-on-yellow mfVEP and significant (P<0.0001) correlation between them (correlation coefficient, 0.73). Abnormal amplitude was detected in 3 of 60 eyes of control subjects (95% specificity). There was, however, no correlation between visual field defect and latency delay in glaucoma patients. Although there was a significant difference between averaged latency of control and glaucoma eyes, values considerably overlapped.

CONCLUSIONS:

The blue-on-yellow mfVEP is a sensitive and specific tool for detecting early glaucoma based on amplitude analysis.

PMID:
17822971
DOI:
10.1016/j.ophtha.2006.11.037
[Indexed for MEDLINE]
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