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Biochimie. 2008 Jan;90(1):131-55. Epub 2007 Jul 24.

Targeting telomeres and telomerase.

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  • 1INSERM, U565, Acides nucléiques: dynamique, ciblage et fonctions biologiques, 43 rue Cuvier, CP26, Paris Cedex 05, F-75231, France.

Abstract

Telomeres and telomerase represent, at least in theory, an extremely attractive target for cancer therapy. The objective of this review is to present the latest view on the mechanism(s) of action of telomerase inhibitors, with an emphasis on a specific class of telomere ligands called G-quadruplex ligands, and to discuss their potential use in oncology.

PMID:
17822826
DOI:
10.1016/j.biochi.2007.07.011
[PubMed - indexed for MEDLINE]
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