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Adv Exp Med Biol. 1991;309B:73-6.

Mutational basis of adenine phosphoribosyltransferase deficiency.

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Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, 46202.


The mutational basis of APRT deficiency was studied in non-Japanese and Japanese patients. Fifteen different mutations have been identified altogether. Of these 4 were common, 6 were located in exon 3, and two at the exon 4-intron 4 junction. The common mutations were a missense mutation in exon 3 (asp65----val) and a T insertion at the exon 4-intron 4 junction in non-Japanese patients, a nonsense mutation in exon 3 (trp98----end) in Type I Japanese patients, and an exon 5 missense mutation (met136----thr) in Type II patients. The other mutations in Type I patients consisted mainly of single base changes and small deletions.

[Indexed for MEDLINE]

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