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J Am Soc Nephrol. 2007 Oct;18(10):2649-52. Epub 2007 Sep 5.

Mechanism of hypokalemia in magnesium deficiency.

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1
UT Southwestern Medical Center, Department of Medicine, 5323 Harry Hines Boulevard, Dallas, TX 75390-8856, USA. chou-long.huang@utsouthwestern.edu

Abstract

Magnesium deficiency is frequently associated with hypokalemia. Concomitant magnesium deficiency aggravates hypokalemia and renders it refractory to treatment by potassium. Herein is reviewed literature suggesting that magnesium deficiency exacerbates potassium wasting by increasing distal potassium secretion. A decrease in intracellular magnesium, caused by magnesium deficiency, releases the magnesium-mediated inhibition of ROMK channels and increases potassium secretion. Magnesium deficiency alone, however, does not necessarily cause hypokalemia. An increase in distal sodium delivery or elevated aldosterone levels may be required for exacerbating potassium wasting in magnesium deficiency.

PMID:
17804670
DOI:
10.1681/ASN.2007070792
[Indexed for MEDLINE]
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