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Bioorg Med Chem Lett. 2007 Oct 15;17(20):5600-4. Epub 2007 Aug 22.

Indoloxypropanolamine analogues as 5-HT(1A) receptor antagonists.

Author information

1
Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA. krush@lilly.com

Abstract

Analogues of pindolol, 1-(1H-indol-4-yloxy)-3-isopropylamino-propan-2-ol, were synthesized and evaluated as 5-HT(1A) receptor antagonists. The structural features required for optimal binding to the 5-HT1A receptor are as follows: S-2-propanol linker, 4-indoloxy substituent, and a large lipophilic cyclic amine substituent.

PMID:
17804228
DOI:
10.1016/j.bmcl.2007.07.086
[Indexed for MEDLINE]

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