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Cell. 2007 Sep 7;130(5):784-95.

Imaging in systems biology.

Author information

1
Beckman Institute, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. megason@hms.harvard.edu

Abstract

Most systems biology approaches involve determining the structure of biological circuits using genomewide "-omic" analyses. Yet imaging offers the unique advantage of watching biological circuits function over time at single-cell resolution in the intact animal. Here, we discuss the power of integrating imaging tools with more conventional -omic approaches to analyze the biological circuits of microorganisms, plants, and animals.

PMID:
17803903
DOI:
10.1016/j.cell.2007.08.031
[Indexed for MEDLINE]
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