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J Clin Invest. 2007 Sep;117(9):2382-5.

Deepening our understanding of immune sentinels in the skin.

Author information

1
St. John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London School of Medicine, London, United Kingdom. frank.nestle@kcl.ac.uk

Abstract

Advances in our understanding of the skin immune system have a major impact on studies of skin autoimmunity, graft-versus-host disease, inflammation, and cancer as well as on the development of novel vaccines and immunotherapy approaches. In this issue of the JCI, Zaba et al. carefully dissected the complex network of DCs and macrophages residing in normal human skin and defined novel phenotypic markers for these immunocytes (see the related article beginning on page 2517). These studies provide the basis for better insight into the role of important immune sentinels contributing to the maintenance of skin tissue homeostasis and lay the foundation for future studies of the skin immune system.

PMID:
17786233
PMCID:
PMC1952646
DOI:
10.1172/JCI33349
[Indexed for MEDLINE]
Free PMC Article

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