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Ann N Y Acad Sci. 2007 Aug;1109:1-8.

The nature and nurture of common autoimmunity.

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1
Cellular Biology and Immunogenetics Unit, Corporación para Investigaciones Biológicas, Medellín, Colombia.

Abstract

Autoimmune diseases are a heterogeneous group of disorders where multiple alterations in the immune system result in a spectrum of syndromes that either target specific organs or affect the body systematically. Although their heterogeneity is due to a collection of diverse conditions based on epidemiology, pathology, or diagnostic criteria, the underlying immunogenetic mechanism might be similar. Herein the nature and nurture of autoimmune diseases considered as a trait are reviewed, and a discussion is given on their multifactorial characteristics.

PMID:
17785284
DOI:
10.1196/annals.1398.001
[Indexed for MEDLINE]
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