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Ann Nutr Metab. 1991;35(5):292-6.

Bioavailability assessment of the lipophilic benfotiamine as compared to a water-soluble thiamin derivative.

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1
FB 6 - Home Economics, Section Nutritional Science, University Paderborn, FRG.

Abstract

The bioequivalence of thiamin in 2 therapeutically used preparations was tested in 10 healthy young men. Thiamin was orally administered either as lipophilic benfotiamine or as water-soluble thiamin mononitrate. Biokinetic data, measured as area under the curve and maximal concentration in plasma and hemolysate after ingestion, demonstrated a significantly improved bioavailability from the lipophilic derivative despite an ingested dose of only 40% as compared with the water-soluble salt. A superior cellular efficacy of benfotiamine was also concluded from the short-term stimulation of the thiamin-dependent transketolase activity in erythrocytes.

PMID:
1776825
DOI:
10.1159/000177659
[Indexed for MEDLINE]

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