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Trends Neurosci. 2007 Sep;30(9):447-55. Epub 2007 Aug 31.

The debate on the kiss-and-run fusion at synapses.

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National Institute of Neurological Disorders and Stroke, 35 Convent Drive, Bldg 35, Rm. 2B-1012, Bethesda, MD 20892, USA.


It has long been proposed that following vesicle fusion, a small pore might open and close rapidly without full dilation. Such 'kiss-and-run' vesicle fusion can in principle result in rapid vesicle recycling and influence the size and the kinetics of the resulting synaptic current. However, the existence of kiss-and-run remains highly controversial, as revealed by recent imaging and electrophysiological studies at several synapses, including hippocampal synapses, neuromuscular junctions and retinal bipolar synapses. Only a minor fraction of fusion events has been shown to be kiss-and-run, as determined using cell-attached capacitance recordings in endocrine cells, pituitary nerve terminals and calyx-type synapses. Further work is needed to determine whether kiss-and-run is a major mode of fusion and has a major role in controlling synaptic strength at synapses.

[Indexed for MEDLINE]

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