Antagonizing Methuselah to extend life span

Genome Biol. 2007;8(8):222. doi: 10.1186/gb-2007-8-8-222.

Abstract

A recent report describes the identification through the use of in vitro selection of a peptide that antagonizes Methuselah signaling in Drosophila in vitro and extends fly life span in vivo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Drosophila Proteins / antagonists & inhibitors*
  • Drosophila Proteins / chemistry
  • Drosophila melanogaster / physiology*
  • Drug Design*
  • Ligands
  • Longevity / drug effects*
  • Oligopeptides / pharmacology*
  • Protein Conformation
  • Receptors, G-Protein-Coupled / antagonists & inhibitors*
  • Receptors, G-Protein-Coupled / chemistry

Substances

  • Drosophila Proteins
  • Ligands
  • Oligopeptides
  • Receptors, G-Protein-Coupled
  • arginyl-tryptophyl-arginine
  • mth protein, Drosophila