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Org Lett. 2007 Sep 27;9(20):3877-80. Epub 2007 Sep 1.

Inactivation of thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity.

Author information

1
Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, PRC.

Abstract

Selective inactivation of cytosolic thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity was studied, which provides an example for rationally developing mechanism-based inhibitors based on a side activity of the enzyme, and may become a supplemental method for better treatment of cardiovascular disease and cancer.

PMID:
17764185
DOI:
10.1021/ol0712677
[Indexed for MEDLINE]

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