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Muscle Nerve. 2007 Dec;36(6):740-55.

Structure-function relations of the giant elastic protein titin in striated and smooth muscle cells.

Author information

1
Department of Veterinary and Comparative Anatomy, Pharmacology Physiology, and Physiology, Washington State University, Pullman, Washington, USA.

Abstract

The striated muscle sarcomere contains, in addition to thin and thick filaments, a third myofilament comprised of titin. The extensible region of titin spans the I-band region of the sarcomere and develops passive force in stretched sarcomeres. This force positions the A-bands in the middle of the sarcomere, maintains sarcomere length homogeneity and, importantly, is responsible for myocardial passive tension that determines diastolic filling. Recent work suggests that smooth muscle expresses a truncated titin isoform with a short extensible region that is predicted to develop high passive force levels. Several mechanisms for tuning the titin-based passive tension have been discovered that involve alternative splicing as well as posttranslational modification, mechanisms that are at play both during normal muscle function as well as during disease.

PMID:
17763461
DOI:
10.1002/mus.20886
[Indexed for MEDLINE]

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