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J Infect Dis. 2007 Oct 1;196(7):1088-92. Epub 2007 Aug 22.

Unique lipid a modifications in Pseudomonas aeruginosa isolated from the airways of patients with cystic fibrosis.

Author information

1
Department of Medicine, University of Washington, Seattle, WA 98195, USA. rkernst@u.washington.edu

Abstract

Three structural features of lipid A (addition of palmitate [C16 fatty acid], addition of aminoarabinose [positively charged amino sugar residue], and retention of 3-hydroxydecanoate [3-OH C10 fatty acid]) were determined for Pseudomonas aeruginosa isolates from patients with cystic fibrosis (CF; n=86), from the environment (n=13), and from patients with other conditions (n=14). Among P. aeruginosa CF isolates, 100% had lipid A with palmitate, 24.6% with aminoarabinose, and 33.3% retained 3-hydroxydecanoate. None of the isolates from the environment or from patients with other conditions displayed these modifications. These results indicate that unique lipid A modifications occur in clinical P. aeruginosa CF isolates.

PMID:
17763333
PMCID:
PMC2723782
DOI:
10.1086/521367
[Indexed for MEDLINE]
Free PMC Article

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