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Am J Clin Oncol. 2007 Aug;30(4):428-31.

Phase II clinical trial of docetaxel in refractory squamous cell carcinoma of the cervix: a Gynecologic Oncology Group Study.

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1
Premiere Oncology, Santa Monica, CA, USA.

Abstract

OBJECTIVE:

A phase II study was conducted to evaluate the antitumor activity and adverse effects of docetaxel in patients with previously treated squamous cell carcinoma of the cervix.

METHODS:

Eligible patients were to have measurable disease and not more than one prior chemotherapy regimen. Docetaxel 100 mg/m was administered intravenously over 1 hour. This treatment was repeated every 21 days until progression of disease or adverse effects prohibited further therapy.

RESULTS:

Twenty-seven patients were entered onto this study, of whom 23 were eligible and evaluable. There were 2 (8.7%) partial responses. Eight patients (34.8%) had stable disease and 9 patients (39.1%) had increasing disease. The median time to progression was 3.8 months (range, 1.2-11.7 months), while median survival time was 7.0 months (range, 1.8-23.0 months). The most frequently reported adverse events were neutropenia, infection, gastrointestinal, and constitutional.

CONCLUSIONS:

Docetaxel has minimal activity in refractory squamous cell carcinoma of the cervix at the dose and schedule tested.

PMID:
17762444
DOI:
10.1097/COC.0b013e31803377c8
[Indexed for MEDLINE]

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