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Clin Neuropharmacol. 2007 Jul-Aug;30(4):201-5.

The effect of duloxetine on primary pain symptoms in Parkinson disease.

Author information

1
Department of Neurology, Rabin Medical Center, Beilinson Hospital, Petah Tiqva, Israel. ruthdjal@clalit.org.il

Abstract

OBJECTIVES:

To study the effect of duloxetine (Cymbalta), a selective serotonin and norepinephrine reuptake inhibitor, on pain symptoms in Parkinson Disease (PD).

METHODS/PATIENTS:

Twenty-three patients with PD with painful phenomena were treated with duloxetine for 6 weeks in an open-label design. Assessments were performed before and at treatment completion and consisted of a Visual Analogue Scale, the Brief Pain Inventory, Short-Form McGill Pain Questionnaire, Parkinson Disease Quality of Life Questionnaire-39-item version, and motor part of the Unified Parkinson Disease Rating Scale. Pain threshold was assessed by quantitative sensory tests.

RESULTS:

Thirteen of the 20 patients who completed the study reported varying degrees of pain relief. The mean Visual Analogue Scale, Brief Pain Inventory, and Short-Form McGill Pain Questionnaire scores decreased significantly. There was no change in pain threshold after treatment.

CONCLUSIONS:

Duloxetine seems to be effective for the treatment of central pain in PD.

PMID:
17762316
DOI:
10.1097/wnf.0b013e3180340319
[Indexed for MEDLINE]

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