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Stroke. 2007 Oct;38(10):2861-3. Epub 2007 Aug 30.

A new hippocampal model for examining intracerebral hemorrhage-related neuronal death: effects of deferoxamine on hemoglobin-induced neuronal death.

Abstract

BACKGROUND AND PURPOSE:

There is an urgent need to develop a model in which to study the mechanism of intracerebral hemorrhage-induced neuronal death in vivo.

METHODS:

This study was divided into 2 parts: (1) Rats received either an infusion of hemoglobin, ferrous iron, or saline into the right hippocampus; (2) Rats had an infusion of hemoglobin and then were treated with either deferoxamine or vehicle. Rats were killed for hippocampus size, DNA damage, and neuronal death measurements.

RESULTS:

Compared with saline, hemoglobin or iron injection caused hippocampal neuronal death. Systemic use of deferoxamine reduced hemoglobin-induced DNA damage, hippocampal neuronal death, and atrophy.

CONCLUSIONS:

This article demonstrates a new model and indicates that iron has a key role in hemoglobin-induced neuronal death.

PMID:
17761912
DOI:
10.1161/STROKEAHA.107.488015
[Indexed for MEDLINE]

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