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Trends Biochem Sci. 1991 Nov;16(11):402-8.

The complexities of eukaryotic transcription initiation: regulation of preinitiation complex assembly.

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Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, NY 10021.


Individual steps in the assembly of RNA polymerase II and general initiation factors into a preinitiation complex serve as points of control for activators, whose functions require additional cofactors. The full range of induction by activators appears to involve both the reversal of negative constraints and net positive effects on promoter interactions with general factors.

[Indexed for MEDLINE]

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