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Trends Biochem Sci. 1991 Nov;16(11):397-402.

Prokaryotic transcriptional enhancers and enhancer-binding proteins.

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Department of Plant Pathology, University of California, Berkeley 94720.


A number of prokaryotic enhancer-binding proteins activate transcription by specialized forms of RNA polymerase. The enhancer-binding proteins catalyse isomerization of the initial complex formed between RNA polymerase and a promoter from the closed to the open state. To do so, one class of enhancer-binding proteins contacts its cognate polymerase by DNA loop formation but the other, which is represented by a single member, does not. Despite this difference, both classes of enhancer-binding proteins must hydrolyse ATP to catalyse open complex formation.

[Indexed for MEDLINE]

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