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J Periodontal Res. 2007 Oct;42(5):410-9.

Susceptibility of various oral bacteria to antimicrobial peptides and to phagocytosis by neutrophils.

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1
Program of Oromaxillofacial Infection & Immunity and BK21, School of Dentistry, Seoul National University, Seoul, Korea.

Erratum in

  • J Periodontal Res. 2008 Feb;43(1):126.

Abstract

BACKGROUND AND OBJECTIVE:

The aim of this study was to compare the susceptibility of nonperiodontopathic and periodontopathic bacteria to major defense mechanisms for bacterial clearance in gingival sulcus.

MATERIAL AND METHODS:

Twenty strains of 13 oral bacterial species were studied for their susceptibility to phagocytosis by human neutrophils and to the antimicrobial peptides LL-37 and human beta defensin-3. The minimum inhibitory concentrations of LL-37 and human beta defensin-3 were determined by a liquid dilution assay, and susceptibility to phagocytosis was examined by a flow cytometric phagocytosis assay.

RESULTS:

The minimum inhibitory concentrations of LL-37 and human beta defensin-3 varied greatly, depending on the strain and species. Although a significant difference between the non- and periodontopathic groups was not observed, the red-complex bacteria were more resistant to LL-37 than the others (p=0.004). The susceptibility of oral bacteria to phagocytosis was quite variable, depending on the species but not on the strains. The periodontopathic bacteria, especially Actinobacillus actinomycetemcomitans and the red-complex triad, were more resistant to phagocytosis than were the nonperiodontopathic bacteria (p=0.0003). In addition, bacteria resistant both to antimicrobial peptides and to phagocytosis were more common in the periodontopathic group.

CONCLUSION:

Our results indicate that immune evasion may contribute to the pathogenicity of some periodontopathic bacteria.

[Indexed for MEDLINE]

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