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Int J Neurosci. 2007 Oct;117(10):1443-56.

Effects of testosterone and growth hormone on long-term retention and extinction of a passive avoidance response in young and aged rats.

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Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F., México.


Wistar rats were divided into two blocks: young and aged. Each block was then randomly divided into the following groups: (1) Control (saline solution), (2) Growth Hormone (GH), (3) Testosterone enanthate, and (4) GH plus testosterone enanthate. Animals were trained on a one-trial passive avoidance conditioning and tested for retention 24 h after training and thereafter twice a week until the extinction response occurred. Results showed that GH, testosterone, and GH plus testosterone improved long-term memory in young rats. Both GH and testosterone delayed the extinction process in young and aged rats. The GH-testosterone interaction delayed the extinction only in young rats.

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