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Neuropsychopharmacology. 2008 Jan;33(1):18-41. Epub 2007 Aug 29.

Synaptic plasticity: multiple forms, functions, and mechanisms.

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1
Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University School of Medicine, Palo Alto, CA 94304-5485, USA.

Abstract

Experiences, whether they be learning in a classroom, a stressful event, or ingestion of a psychoactive substance, impact the brain by modifying the activity and organization of specific neural circuitry. A major mechanism by which the neural activity generated by an experience modifies brain function is via modifications of synaptic transmission; that is, synaptic plasticity. Here, we review current understanding of the mechanisms of the major forms of synaptic plasticity at excitatory synapses in the mammalian brain. We also provide examples of the possible developmental and behavioral functions of synaptic plasticity and how maladaptive synaptic plasticity may contribute to neuropsychiatric disorders.

PMID:
17728696
DOI:
10.1038/sj.npp.1301559
[Indexed for MEDLINE]
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