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Brain. 2007 Dec;130(Pt 12):3149-54. Epub 2007 Aug 29.

Distinct regional atrophy in the corpus callosum of patients with temporal lobe epilepsy.

Author information

1
Department of Epileptology, University of Bonn, Germany. bernd.weber@ukb.uni-bonn.de

Abstract

We analysed the influence of mesial temporal lobe epilepsy on the thickness of the corpus callosum (CC) in a large sample of well-characterized patients (n = 96) and healthy controls (n = 28). In particular, we investigated whether callosal structures are differentially affected depending on the affected hemisphere and age of epilepsy onset. Overall, we observed that epilepsy is associated with a decreased thickness in posterior callosal regions. Patients with an early onset, especially patients with left onset, additionally exhibited a smaller callosal thickness in more anterior and midbody regions. These findings may reflect non-specific as well as specific effects of temporal lobe epilepsy on CC development and interhemispheric connectivity.

PMID:
17728360
PMCID:
PMC2770440
DOI:
10.1093/brain/awm186
[Indexed for MEDLINE]
Free PMC Article
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