Format

Send to

Choose Destination
See comment in PubMed Commons below
Thromb J. 2007 Aug 29;5:11.

Anithrombotic prevention in vascular disease: bases for a new strategy in antithrombotic therapy.

Author information

  • 1Centro de Trombosis de Buenos Aires, Buenos Aires, Argentina. draltman@arnet.com.ar.

Abstract

A tendency toward bleeding often undercuts the beneficial preventive effect of higher doses of a single antithrombotic drug or combined antithrombotic therapy. Although high doses of antithrombotic drugs may be necessary for optimal prevention, such therapy can also elicit more frequent bleeding. Although major bleeding could be a reversible event is likely to lead clinicians to discontinue antithrombotic therapy which in turn could increase the risk of myocardial infarction, stroke, and cardiovascular death. Thus, to prevent thrombotic events without frequent bleeding complications, the preferred approach might be to use anti-inflammatory drugs in addition to the first-line antithrombotic drugs to reduce inflammation and thrombin formation in atheroma. Although some preliminary data have been already published, to confirm the potential benefit of anti-inflammatory drugs in acute coronary syndromes large prospective double-bind randomized trials are necessary.

PMID:
17727726
PMCID:
PMC2040133
DOI:
10.1186/1477-9560-5-11
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Support Center