Format

Send to

Choose Destination
Immunity. 2007 Aug;27(2):183-5.

Islet beta-cell death - fuel to sustain autoimmunity?

Author information

1
La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. christophe@liai.org

Abstract

Under what context do dying beta-cells enhance the autoimmune process in type 1 diabetes? Kim et al. (2007) find that secondary necrosis of beta-cells can prime the autoimmune response via uptake by and activation of antigen-presenting cells through Toll-like receptor 2.

PMID:
17723211
DOI:
10.1016/j.immuni.2007.08.002
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center