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Acta Pharmacol Sin. 2007 Sep;28(9):1343-54.

Discovery and development of sulforaphane as a cancer chemopreventive phytochemical.

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1
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. yuesheng.zhang@roswellpark.org

Abstract

Sulforaphane (SF) is a phytochemical that displays both anticarcinogenic and anticancer activity. SF modulates many cancer-related events, including susceptibility to carcinogens, cell death, cell cycle, angiogenesis, invasion and metastasis. We review its discovery and development as a cancer chemopreventive agent with the intention of encouraging further research on this important compound and facilitating the identification and development of new phytochemicals for cancer prevention.

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