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Nat Med. 2007 Sep;13(9):1032-4. Epub 2007 Aug 26.

Broad HIV-1 neutralization mediated by CD4-binding site antibodies.

Author information

1
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

Abstract

We have identified several patient sera showing potent and broad HIV-1 neutralization. Using antibody adsorption and elution from selected gp120 variants, the neutralizing specificities of the two most broadly reactive sera were mapped to the primary receptor CD4-binding region of HIV-1 gp120. Novel antibodies to the CD4-binding site are elicited in some HIV-1-infected individuals, and new approaches to present this conserved region of gp120 to the immune system may result in improved vaccine immunogens.

PMID:
17721546
PMCID:
PMC2584972
DOI:
10.1038/nm1624
[Indexed for MEDLINE]
Free PMC Article

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