Format

Send to

Choose Destination
See comment in PubMed Commons below
Genetics. 2007 Nov;177(3):1963-6. Epub 2007 Aug 24.

Significance thresholds for quantitative trait locus mapping under selective genotyping.

Author information

1
Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland 21205, USA.

Abstract

In the case of selective genotyping, the usual permutation test to establish statistical significance for quantitative trait locus (QTL) mapping can give inappropriate significance thresholds, especially when the phenotype distribution is skewed. A stratified permutation test should be used, with phenotypes shuffled separately within the genotyped and ungenotyped individuals.

PMID:
17720902
PMCID:
PMC2147971
DOI:
10.1534/genetics.107.080093
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center