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Protein Eng Des Sel. 2007 Oct;20(10):521-3. Epub 2007 Aug 24.

The PASTA server for protein aggregation prediction.

Author information

1
Department of Physics G. Galilei, University of Padova, Padova, Italy.

Abstract

Many different proteins aggregate into amyloid fibrils characterized by cross-beta structure. beta-strands contributed by distinct protein molecules are generally found in a parallel in-register alignment. Here, we describe the web server for a novel algorithm, prediction of amyloid structure aggregation (PASTA), to predict the most aggregation-prone portions and the corresponding beta-strand inter-molecular pairing for a given input sequence. PASTA was previously shown to yield results in excellent agreement with available experimental observations, when tested on both natively unfolded and structured proteins. The web server and downloadable source code are freely accessible from the URL: http://protein.cribi.unipd.it/pasta/.

PMID:
17720750
DOI:
10.1093/protein/gzm042
[Indexed for MEDLINE]

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