The function of Dmrt genes in vertebrate development: it is not just about sex

Chang-Soo Hong; Byung-Yong Park; Jean-Pierre Saint-Jeannet

doi:10.1016/j.ydbio.2007.07.035

The function of Dmrt genes in vertebrate development: it is not just about sex

Dev Biol. 2007 Oct 1;310(1):1-9. doi: 10.1016/j.ydbio.2007.07.035. Epub 2007 Aug 3.

Authors

Chang-Soo Hong¹, Byung-Yong Park, Jean-Pierre Saint-Jeannet

Affiliation

¹ Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA.

PMID: 17720152
DOI: 10.1016/j.ydbio.2007.07.035

Abstract

The Dmrt genes encode a large family of transcription factors whose function in sexual development has been well studied in invertebrates and vertebrates. Their expression pattern is not restricted to the developing gonads, indicating that Dmrt genes might regulate other developmental processes. Here we review the expression pattern of several members of this family across species and summarize recent findings on the function of a subset of these genes in non-gonadal tissues.

Publication types

Review

MeSH terms

Animals
Caenorhabditis elegans Proteins / genetics
DNA-Binding Proteins / genetics*
Drosophila Proteins / genetics
Evolution, Molecular
Gene Expression Regulation, Developmental*
Human Development
Humans
Organ Specificity
Sex Determination Processes*
Sex Differentiation*
Sexual Behavior
Transcription Factors / genetics*

Substances

Caenorhabditis elegans Proteins
DMRT1 protein
DNA-Binding Proteins
DSX protein, Drosophila
Drosophila Proteins
Mab-3 protein, C elegans
Transcription Factors