Format

Send to

Choose Destination
See comment in PubMed Commons below
Vet J. 2008 Oct;178(1):115-8. Epub 2007 Aug 23.

Tissue distribution of marbofloxacin after 'systemic' administration into the isolated perfused bovine udder.

Author information

1
Institute for Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Foundation, B├╝nteweg 17, D-30559 Hannover, Germany. manfred.kietzmann@tiho-hannover.de

Abstract

Mammary glands taken at slaughter from healthy lactating cows were perfused in vitro with warmed and gassed Tyrode solution. Marbofloxacin was administered "systemically" via the perfusion fluid at concentrations similar to those measured in plasma following intravenous administration of 2mg/kg marbofloxacin. Samples from the perfusate were taken over a 24h period. Glandular tissue samples at different vertical distances from the teat up to the udder base were gathered from each of the four quarters after 3, 6, 12 and 24h. The marbofloxacin content of the tissue samples was analysed by high performance liquid chromatography with UV detection. The addition of marbofloxacin to the perfusion fluid produced median concentrations above the MIC90 (0.016microg/mL) against Escherichia coli at all glandular tissue sites measured after 3 and 6h with remarkable variations. Samples taken after 12 and 24h contained marbofloxacin in concentrations (median) of 0.22 (<0.05-0.32)microg/g and 0.13 (<0.05-0.16)microg/g. It is concluded that a systemic administration of marbofloxacin is well suited for the treatment of E. coli mastitis.

PMID:
17719251
DOI:
10.1016/j.tvjl.2007.06.020
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center