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Stroke. 2007 Oct;38(10):2733-7. Epub 2007 Aug 23.

Iron oxide particle-enhanced MRI suggests variability of brain inflammation at early stages after ischemic stroke.

Author information

1
Institute of Diagnostic Radiology, Heinrich-Heine-University, Moorenstr. 5, D-40225 Düsseldorf, Germany.

Abstract

BACKGROUND AND PURPOSE:

Inflammation contributes to brain damage caused by ischemic stroke. Ultrasmall superparamagnetic iron oxide (USPIO)-enhanced MRI allows noninvasive monitoring of macrophage recruitment into ischemic brain lesions. In this study, we determined the extent of USPIO enhancement during early stages of ischemic stroke.

METHODS:

Twelve consecutive patients with typical clinical signs of stroke underwent multimodal stroke imaging at 1.5-T within 24 hours of symptom onset. They received intravenous USPIO (ferumoxtran) infusion at 26 to 96 hours (mean, 44 hours) after stroke. A total of four follow-up MRI scans were performed 24 to 36 hours, 48 to 72 hours, 7 to 8 days, and 10 to 11 days after USPIO infusion.

RESULTS:

Nine patients were included in the final analysis. Parenchymal USPIO enhancement occurred in 3 of 9 analyzed patients and was mainly evident on T1-weighted spin-echo images. USPIO-dependent signal changes were spatially heterogeneous, reflecting the distinct patterns of hematogenous macrophage infiltration in different lesion types.

CONCLUSIONS:

Our findings suggest a variable extent and distribution of macrophage infiltration into early ischemic stroke lesions. USPIO-enhanced MRI may help to more specifically target antiinflammatory therapy in patients with stroke.

PMID:
17717318
DOI:
10.1161/STROKEAHA.107.481788
[Indexed for MEDLINE]
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