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Bioorg Med Chem Lett. 2007 Oct 1;17(19):5370-3. Epub 2007 Aug 11.

Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies.

Author information

1
Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via A. De Gasperi 2, I-53100 Siena, Italy.

Abstract

The identification of a novel hit compound as integrase binding inhibitor has been accomplished by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with one of the compounds showing an IC(50)=12 microM.

PMID:
17716893
DOI:
10.1016/j.bmcl.2007.08.005
[Indexed for MEDLINE]

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