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Curr Opin Immunol. 2007 Oct;19(5):577-82. Epub 2007 Aug 22.

Acceleration of allograft failure by cytomegalovirus.

Author information

1
MMI, OHSU, Portland, OR, United States.

Abstract

A number of human herpesviruses are important opportunistic pathogens that have been associated with increased morbidity and mortality in transplant recipients including human cytomegalovirus (HCMV), HHV6, HHV7, HHV8 as well as HSV-1, VZV. However, HCMV has been linked both epidemiologically and through the use of animal models to the acceleration of acute and chronic allograft rejection. This review will cover the pathophysiology, epidemiology, and mechanisms of CMV-associated disease in the setting of transplantation.

PMID:
17716883
PMCID:
PMC3509935
DOI:
10.1016/j.coi.2007.07.012
[Indexed for MEDLINE]
Free PMC Article

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